Sodium Methoxide-Catalyzed Direct Amidation of Esters
نویسندگان
چکیده
منابع مشابه
Sodium methoxide: a simple but highly efficient catalyst for the direct amidation of esters.
A simple NaOMe catalyst provides superior accessibility to a wide variety of functionalized amides including peptides through direct amination of esters in an atom-economical and environmentally benign way.
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Go catalytic! A catalytic enantioselective protonation of alkenyl trifluoroacetates was achieved by using an in situ generated chiral tin bromide methoxide as the chiral catalyst in the presence of methanol. Optically active ketones containing a tertiary stereogenic center at the α-position were obtained with enantioselectivities of up to 94 % ee.
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A Cu-catalyzed aromatic C-H amidation with phthalimide under oxygen as a terminal oxidant without using additional additives has been achieved. This reaction has the broad substrate scope and shows moderate to good yields in most cases. This method is complementary to the previously reported metal-catalyzed C-H amination systems.
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ژورنال
عنوان ژورنال: Organic Syntheses
سال: 2014
ISSN: 2333-3553
DOI: 10.15227/orgsyn.091.0201